myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of dl-myo-inositol 1,4-bisphosphate and dl-myo-inositol 1,4-bisphosphorothioate

myo-Inositol phosphorothioates, phosphatase-resistant analogues

Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (± )1,2: 4,5-di-isopropylidene-myo-inositol. The synthesis of (± )1,2: 4,5-di-isopropylidene 3,6-bis[di-(2cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the cor...

Synthesis of fluorodeoxy analogues of myo-inositol.

Accumulating evidence strongly suggests that the action of a phospholipase C on phosphoinositides in the cell membrane in response to the activation of a receptor is an integral part of an intracellular signalling pathway. Specific inhibitors of this enzyme and the site-specific kinases involved in inositide metabolism are urgently required to establish their function. An approach to the design...

Role of myo-inositol

myo-Inositol metabolism in plants

The multifunctional position supplied by myo-inositol is emerging as a central feature in plant biochemistry and physiology. In this critique, attention is drawn to metabolic aspects and current assessment is made of manifold ways in which myo-inositol and its metabolic products impact growth and development. The fact that a unique enzyme, common to all eukaryotic organisms where such assessmen...

2-Benzyl-myo-inositol monohydrate

The title structure, C(13)H(18)O(6)·H(2)O, contains two independent 2-benzyl-myo-inositol and water mol-ecules. In the crystal, the mol-ecules are strongly hydrogen bonded into an infinite two dimensional network utilizing all OH protons.